HCN4-like immunoreactivity in rat retinal ganglion cells

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HCN4-like immunoreactivity in rat retinal ganglion cells.

Antisera directed against hyperpolarization-activated, cyclic nucleotide-sensitive (HCN) channels bind to somata in the ganglion cell layer of rat and rabbit retinas, and mRNA for different HCN channel isoforms has been detected in the ganglion cell layer of mouse retina. However, previous studies neither provided evidence that any of the somata are ganglion cells (as opposed to displaced amacr...

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Retinal ganglion cells (RGCs) in rats were retrogradely labeled with the fluorescent tracer Fluorogold (FG) and subjected to GAP-43 and c-JUN immunocytochemistry to identify those RGCs that are capable of regenerating an axon. After optic nerve section (ONS) and simultaneous application of FG to the nerve stump (group 1 experiments), GAP-43 immunoreactive RGCs (between 2 and 21 days after ONS) ...

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Frequency Responses of Rat Retinal Ganglion Cells

There are 15-20 different types of retinal ganglion cells (RGC) in the mammalian retina, each encoding different aspects of the visual scene. The mechanism by which post-synaptic signals from the retinal network generate spikes is determined by each cell's intrinsic electrical properties. Here we investigate the frequency responses of morphologically identified rat RGCs using intracellular inje...

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Recent functional data has raised the possibility that an excitatory amino acid, such as glutamate, may act as neurotransmitter in vibrissal type I slowly adapting (St I) mechanoreceptors. It is supposed that Merkel cells respond to mechanical stimulation by releasing a neurotransmitter which acts on the nerve terminals in contact with the Merkel cells. Therefore, we sought to establish whether...

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Ih without Kir in adult rat retinal ganglion cells.

Antisera directed against hyperpolarization-activated mixed-cation ("I(h)") and K(+) ("K(ir)") channels bind to some somata in the ganglion cell layer of rat and rabbit retina. Additionally, the termination of hyperpolarizing current injections can trigger spikes in some cat retinal ganglion cells, suggesting a rebound depolarization arising from activation of I(h). However, patch-clamp studies...

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ژورنال

عنوان ژورنال: Visual Neuroscience

سال: 2008

ISSN: 0952-5238,1469-8714

DOI: 10.1017/s095252380808005x